Activity-dependent potentiation of calcium signals in spinal sensory networks in inflammatory pain states
C Luo, PH Seeburg, R Sprengel, R Kuner - Pain, 2008 - Elsevier
The second messenger calcium is a key mediator of activity-dependent neural plasticity.
How persistent nociceptive activity alters calcium influx and release in the spinal cord is not
well-understood. We performed calcium-imaging on individual cell bodies and the whole
area within laminae I and II in spinal cord slices from mice in the naïve state or 24h following
unilateral hindpaw plantar injection of complete Freund's adjuvant. Calcium signals evoked
by dorsal root stimulation at varying strengths displayed a steep rise and slow decay over 15 …
How persistent nociceptive activity alters calcium influx and release in the spinal cord is not
well-understood. We performed calcium-imaging on individual cell bodies and the whole
area within laminae I and II in spinal cord slices from mice in the naïve state or 24h following
unilateral hindpaw plantar injection of complete Freund's adjuvant. Calcium signals evoked
by dorsal root stimulation at varying strengths displayed a steep rise and slow decay over 15 …