How patients have benefited from mouse models of acute promyelocytic leukaemia
V Lallemand-Breitenbach, J Zhu, S Kogan… - Nature Reviews …, 2005 - nature.com
V Lallemand-Breitenbach, J Zhu, S Kogan, Z Chen, H de Thé
Nature Reviews Cancer, 2005•nature.comOne of the challenges of studying anticancer therapies is that effects observed in cell lines or
mouse models are not always good indicators of clinical trial results. The mouse model of
acute promyelocytic leukaemia has bucked this trend, as targeted therapies such as retinoic
acid and arsenic induce differentiation and clearance of leukaemia cells in both mice and
humans. This mouse model has also provided important mechanistic insights into the
combinatorial effects of these agents and has promoted combined therapies that have …
mouse models are not always good indicators of clinical trial results. The mouse model of
acute promyelocytic leukaemia has bucked this trend, as targeted therapies such as retinoic
acid and arsenic induce differentiation and clearance of leukaemia cells in both mice and
humans. This mouse model has also provided important mechanistic insights into the
combinatorial effects of these agents and has promoted combined therapies that have …
Abstract
One of the challenges of studying anticancer therapies is that effects observed in cell lines or mouse models are not always good indicators of clinical trial results. The mouse model of acute promyelocytic leukaemia has bucked this trend, as targeted therapies such as retinoic acid and arsenic induce differentiation and clearance of leukaemia cells in both mice and humans. This mouse model has also provided important mechanistic insights into the combinatorial effects of these agents and has promoted combined therapies that have shown recent success in the clinic.
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