[HTML][HTML] Role of antisense RNA in coordinating cardiac myosin heavy chain gene switching
F Haddad, PW Bodell, AX Qin, JM Giger… - Journal of Biological …, 2003 - ASBMB
A novel mechanism of regulation of cardiac α and β myosin heavy chain gene by naturally
occurring antisense transcription was elucidated via pre-mRNA analysis. Herein, we report
the expression of an antisense β myosin heavy chain RNA in the normal rodent
myocardium. The pattern of expression of the antisense βMHC RNA (β RNA) under altered
thyroid state and in diabetes directly correlates with that of the α pre-mRNA/mRNA, whereas
it negatively correlates with the β mRNA expression. Rapid amplification of the 5′ end …
occurring antisense transcription was elucidated via pre-mRNA analysis. Herein, we report
the expression of an antisense β myosin heavy chain RNA in the normal rodent
myocardium. The pattern of expression of the antisense βMHC RNA (β RNA) under altered
thyroid state and in diabetes directly correlates with that of the α pre-mRNA/mRNA, whereas
it negatively correlates with the β mRNA expression. Rapid amplification of the 5′ end …