[HTML][HTML] Acylation state of the phosphatidylinositol mannosides from Mycobacterium bovis bacillus Calmette Guerin and ability to induce granuloma and recruit natural …
M Gilleron, C Ronet, M Mempel, B Monsarrat… - Journal of Biological …, 2001 - ASBMB
Previous studies have found that, when injected into mice, glycolipidic fractions of
mycobacterial cell walls containing phosphatidylinositol mannosides (PIM) induced a
granuloma and recruitment of Natural Killer T cells in the lesions. The dimannoside (PIM 2)
and the hexamannoside (PIM 6) PIM were isolated from Mycobacterium bovis bacillus
Calmette Guérin and shown to act alike, but the activity was found to be dependent on the
presence of the lipidic part. The chemical structure of PIM was then re-evaluated, focusing …
mycobacterial cell walls containing phosphatidylinositol mannosides (PIM) induced a
granuloma and recruitment of Natural Killer T cells in the lesions. The dimannoside (PIM 2)
and the hexamannoside (PIM 6) PIM were isolated from Mycobacterium bovis bacillus
Calmette Guérin and shown to act alike, but the activity was found to be dependent on the
presence of the lipidic part. The chemical structure of PIM was then re-evaluated, focusing …