Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase
P Tripatara, NSA Patel, A Webb, K Rathod… - Journal of the …, 2007 - journals.lww.com
In normal conditions, nitric oxide (NO) is oxidized to the anion nitrite, but in hypoxia, this
nitrite may be reduced back to NO by the nitrite reductase action of deoxygenated
hemoglobin, acidic disproportionation, or xanthine oxidoreductase (XOR). Herein, is
investigated the effects of topical sodium nitrite administration in a rat model of renal
ischemia/reperfusion (I/R) injury. Rats were subjected to 60 min of bilateral renal ischemia
and 6 h of reperfusion in the absence or presence of sodium nitrite (30 nmol) administered …
nitrite may be reduced back to NO by the nitrite reductase action of deoxygenated
hemoglobin, acidic disproportionation, or xanthine oxidoreductase (XOR). Herein, is
investigated the effects of topical sodium nitrite administration in a rat model of renal
ischemia/reperfusion (I/R) injury. Rats were subjected to 60 min of bilateral renal ischemia
and 6 h of reperfusion in the absence or presence of sodium nitrite (30 nmol) administered …