Interferon alpha—a potential link in the pathogenesis of viral-induced type 1 diabetes and autoimmunity
D Devendra, GS Eisenbarth - Clinical immunology, 2004 - Elsevier
The incidence of type 1 diabetes has been rapidly rising. Environmental factors such as
viruses have been implicated as a possible agent accounting for this rise. Enteroviruses
have recently been the focus in many research studies as a potential agent in the
pathogenesis of type 1 diabetes. The mechanism of viral infection leading to β cell
destruction not only involves multiple pathways but also the cytokine-interferon alpha (IFN-
α). Our hypothesis is that activation of toll receptors by double-stranded RNA or poly-IC (viral …
viruses have been implicated as a possible agent accounting for this rise. Enteroviruses
have recently been the focus in many research studies as a potential agent in the
pathogenesis of type 1 diabetes. The mechanism of viral infection leading to β cell
destruction not only involves multiple pathways but also the cytokine-interferon alpha (IFN-
α). Our hypothesis is that activation of toll receptors by double-stranded RNA or poly-IC (viral …