Cell cycle genes in ovarian cancer: steps toward earlier diagnosis and novel therapies
G D'Andrilli, C Kumar, G Scambia, A Giordano - Clinical cancer research, 2004 - AACR
G D'Andrilli, C Kumar, G Scambia, A Giordano
Clinical cancer research, 2004•AACRHuman malignant tumors are characterized by abnormal proliferation resulting from
alterations in cell cycle-regulatory mechanisms. The regulatory pathways controlling cell
cycle phases include several oncogenes and tumor suppressor genes that display a range
of abnormalities with potential usefulness as markers of evolution or treatment response in
ovarian cancer. This review summarizes the current knowledge about these aberrations in
malignant tumors of the ovary. We sought to divide cell cycle-regulatory genes into four …
alterations in cell cycle-regulatory mechanisms. The regulatory pathways controlling cell
cycle phases include several oncogenes and tumor suppressor genes that display a range
of abnormalities with potential usefulness as markers of evolution or treatment response in
ovarian cancer. This review summarizes the current knowledge about these aberrations in
malignant tumors of the ovary. We sought to divide cell cycle-regulatory genes into four …
Abstract
Human malignant tumors are characterized by abnormal proliferation resulting from alterations in cell cycle-regulatory mechanisms. The regulatory pathways controlling cell cycle phases include several oncogenes and tumor suppressor genes that display a range of abnormalities with potential usefulness as markers of evolution or treatment response in ovarian cancer. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary. We sought to divide cell cycle-regulatory genes into four subgroups on the basis of their predominant role in a specific phase or during the transition between two phases of the cell cycle.
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