[HTML][HTML] Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation
CY Soohoo, R Shi, TH Lee, P Huang, KP Lu… - Journal of biological …, 2011 - ASBMB
Telomere maintenance is essential for protecting chromosome ends. Aberrations in
telomere length have been implicated in cancer and aging. Telomere elongation by human
telomerase is inhibited in cis by the telomeric protein TRF1 and its associated proteins.
However, the link between TRF1 and inhibition of telomerase elongation of telomeres
remains elusive because TRF1 has no direct effect on telomerase activity. We have
previously identified one Pin2/TRF1-interacting protein, PinX1, that has the unique property …
telomere length have been implicated in cancer and aging. Telomere elongation by human
telomerase is inhibited in cis by the telomeric protein TRF1 and its associated proteins.
However, the link between TRF1 and inhibition of telomerase elongation of telomeres
remains elusive because TRF1 has no direct effect on telomerase activity. We have
previously identified one Pin2/TRF1-interacting protein, PinX1, that has the unique property …