A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia
A Yokohama, A Mishra, T Mitsui, B Becknell, J Johns… - Leukemia research, 2010 - Elsevier
Murine models of disease are vital to the understanding of pathogenesis and the
development of novel therapeutics. We have previously established interleukin (IL)-15
transgenic (tg) mice that demonstrate rapid proliferation of natural killer (NK) and T cells,
followed by spontaneous transformation to lethal leukemia. Herein, we have characterized
this model, which has many features in common with the aggressive variants of NK and T
large granular lymphocyte leukemia (LGLL) in humans. The LGLL blasts are cytolytic and …
development of novel therapeutics. We have previously established interleukin (IL)-15
transgenic (tg) mice that demonstrate rapid proliferation of natural killer (NK) and T cells,
followed by spontaneous transformation to lethal leukemia. Herein, we have characterized
this model, which has many features in common with the aggressive variants of NK and T
large granular lymphocyte leukemia (LGLL) in humans. The LGLL blasts are cytolytic and …