Interleukin-2, interleukin-15, and their roles in human natural killer cells
B Becknell, MA Caligiuri - Advances in immunology, 2005 - Elsevier
Natural killer (NK) cells are CD56+ CD3− large granular lymphocytes that constitute a key
component of the human innate immune response. In addition to their potent cytolytic
activity, NK cells elaborate a host of immunoregulatory cytokines and chemokines that play a
crucial role in pathogen clearance. Furthermore, interactions between NK and other immune
cells are implicated in triggering the adaptive, or antigen-specific, immune response.
Interleukin-2 (IL-2) and IL-15 are two distinct cytokines with partially overlapping properties …
component of the human innate immune response. In addition to their potent cytolytic
activity, NK cells elaborate a host of immunoregulatory cytokines and chemokines that play a
crucial role in pathogen clearance. Furthermore, interactions between NK and other immune
cells are implicated in triggering the adaptive, or antigen-specific, immune response.
Interleukin-2 (IL-2) and IL-15 are two distinct cytokines with partially overlapping properties …