DAP12 and KAP10 (DAP10)-novel transmembrane adapter proteins of the CD3ζ family
MJ Wilson, JA Lindquist, J Trowsdale - Immunologic research, 2000 - Springer
MJ Wilson, JA Lindquist, J Trowsdale
Immunologic research, 2000•SpringerTransmembrane adapter proteins are molecules that associate with receptors and mediate
intracellular signals following interaction of the receptor with its ligand. Many such molecules
have been characterized in detail, particularly the small TM adapters of the CD3ζ class at the
core of the T cell receptor. Recently, two new genetically linked members of this class of
transmembrane adapters have been identified called DAP12 (KARAP) and KAP10 (DAP10),
respectively. In this review, we discuss this new class of TM adapters using the wealth of …
intracellular signals following interaction of the receptor with its ligand. Many such molecules
have been characterized in detail, particularly the small TM adapters of the CD3ζ class at the
core of the T cell receptor. Recently, two new genetically linked members of this class of
transmembrane adapters have been identified called DAP12 (KARAP) and KAP10 (DAP10),
respectively. In this review, we discuss this new class of TM adapters using the wealth of …
Abstract
Transmembrane adapter proteins are molecules that associate with receptors and mediate intracellular signals following interaction of the receptor with its ligand. Many such molecules have been characterized in detail, particularly the small TM adapters of the CD3ζ class at the core of the T cell receptor. Recently, two new genetically linked members of this class of transmembrane adapters have been identified called DAP12 (KARAP) and KAP10 (DAP10), respectively. In this review, we discuss this new class of TM adapters using the wealth of knowledge concerning CD3ζ and FcRγ to high-light similarities and differences with DAP12 and KAP10. In addition, novel receptor families which interact with these TM adapters have also been identified. The role of these receptors and their inhibitory isoforms are discussed.
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