HLA-A1, B8-phenotype association and HBs antigenemia evolution in 440 hemodialyzed patients
B Descamps, P Jungers, C Naret, C Degott, J Zingraff… - Digestion, 1977 - karger.com
B Descamps, P Jungers, C Naret, C Degott, J Zingraff, JF Bach
Digestion, 1977•karger.comHBs antigen (HBsAg) has been followed up every month in 440 hemodialyzed patients,
typed for 26 HLA alleles of the A and B loci. An abnormally high rate of the HLA-A1, B8
association (18.6%) was found in the group of patients able to eliminate HBsAg, when
compared with the normal French population (5.05%, p< 10-4), and with the group of
patients unable to eliminate HBsAg (7.0%, p< 0.01). Chronic aggressive hepatitis was only
found in the latter. This high frequency of the HLA-A1, B8 association has also been found in …
typed for 26 HLA alleles of the A and B loci. An abnormally high rate of the HLA-A1, B8
association (18.6%) was found in the group of patients able to eliminate HBsAg, when
compared with the normal French population (5.05%, p< 10-4), and with the group of
patients unable to eliminate HBsAg (7.0%, p< 0.01). Chronic aggressive hepatitis was only
found in the latter. This high frequency of the HLA-A1, B8 association has also been found in …
Abstract
HBs antigen (HBsAg) has been followed up every month in 440 hemodialyzed patients, typed for 26 HLA alleles of the A and B loci. An abnormally high rate of the HLA-A1, B8 association (18.6 %) was found in the group of patients able to eliminate HBsAg, when compared with the normal French population (5.05 %, p < 10-4), and with the group of patients unable to eliminate HBsAg (7.0 %, p < 0.01). Chronic aggressive hepatitis was only found in the latter. This high frequency of the HLA-A1, B8 association has also been found in patients with seronegative active chronic hepatitis and suggests that this phenotype might be associated with high immune response against HBsAg.
Karger