Expression of the adhesion molecules ICAM-1, VCAM-1, and E-selectin and their ligands VLA-4 and LFA-1 in chronic venous leg ulcers
A Weyl, W Vanscheidt, JM Weiss, M Peschen… - Journal of the American …, 1996 - Elsevier
Background: Leukocyte binding to endothelial cells (ECs) is thought to contribute to the
pathogenesis of leg ulcers caused by chronic venous insufficiency. In other systems, such
binding is mediated by the interaction of adhesion molecules such as intracellular adhesion
molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin (on ECs),
and leukocyte function-associated antigen-1 (LFA-1) and very late activated antigen-4 (VLA-
4)(on leukocytes). Objective: Our purpose was to determine whether an increased …
pathogenesis of leg ulcers caused by chronic venous insufficiency. In other systems, such
binding is mediated by the interaction of adhesion molecules such as intracellular adhesion
molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin (on ECs),
and leukocyte function-associated antigen-1 (LFA-1) and very late activated antigen-4 (VLA-
4)(on leukocytes). Objective: Our purpose was to determine whether an increased …
