[HTML][HTML] The receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development
I Gross, DJ Morrison, DP Hyink, K Georgas… - Journal of Biological …, 2003 - ASBMB
WT1 encodes a transcription factor involved in kidney development and tumorigenesis.
Using representational difference analysis, we identified a new set of WT1 targets, including
a homologue of the Drosophila receptor tyrosine kinase regulator, sprouty. Sprouty1 was up-
regulated in cell lines expressing wild-type but not mutant WT1. WT1 bound to the
endogenous sprouty1 promoter in vivo and directly regulated sprouty1 through an early
growth response gene-1 binding site. Expression of Sprouty1 and WT1 overlapped in the …
Using representational difference analysis, we identified a new set of WT1 targets, including
a homologue of the Drosophila receptor tyrosine kinase regulator, sprouty. Sprouty1 was up-
regulated in cell lines expressing wild-type but not mutant WT1. WT1 bound to the
endogenous sprouty1 promoter in vivo and directly regulated sprouty1 through an early
growth response gene-1 binding site. Expression of Sprouty1 and WT1 overlapped in the …