Regulation of cancer cell metabolism by hypoxia-inducible factor 1
GL Semenza - Seminars in cancer biology, 2009 - Elsevier
GL Semenza
Seminars in cancer biology, 2009•ElsevierThe induction of hypoxia-inducible factor 1 (HIF-1) activity, either as a result of intratumoral
hypoxia or loss-of-function mutations in the VHL gene, leads to a dramatic reprogramming of
cancer cell metabolism involving increased glucose transport into the cell, increased
conversion of glucose to pyruvate, and a concomitant decrease in mitochondrial metabolism
and mitochondrial mass. Blocking these adaptive metabolic responses to hypoxia leads to
cell death due to toxic levels of reactive oxygen species. Targeting HIF-1 or metabolic …
hypoxia or loss-of-function mutations in the VHL gene, leads to a dramatic reprogramming of
cancer cell metabolism involving increased glucose transport into the cell, increased
conversion of glucose to pyruvate, and a concomitant decrease in mitochondrial metabolism
and mitochondrial mass. Blocking these adaptive metabolic responses to hypoxia leads to
cell death due to toxic levels of reactive oxygen species. Targeting HIF-1 or metabolic …
The induction of hypoxia-inducible factor 1 (HIF-1) activity, either as a result of intratumoral hypoxia or loss-of-function mutations in the VHL gene, leads to a dramatic reprogramming of cancer cell metabolism involving increased glucose transport into the cell, increased conversion of glucose to pyruvate, and a concomitant decrease in mitochondrial metabolism and mitochondrial mass. Blocking these adaptive metabolic responses to hypoxia leads to cell death due to toxic levels of reactive oxygen species. Targeting HIF-1 or metabolic enzymes encoded by HIF-1 target genes may represent a novel therapeutic approach to cancer.
Elsevier