[HTML][HTML] Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-α
Mammalian tissues express three immunologically distinct peroxiredoxin (Prx) proteins (Prx
I, II, and III), which are the products of distinct genes. With the use of recombinant proteins
Prx I, II, and III, all have now been shown to possess peroxidase activity and to rely on Trx as
a source of reducing equivalents for the reduction of H 2 O 2. Prx I and II are cytosolic
proteins, whereas Prx III is localized in mitochondria. Transient overexpression of Prx I or II
in cultured cells showed that they were able to eliminate the intracellular H 2 O 2 generated …
I, II, and III), which are the products of distinct genes. With the use of recombinant proteins
Prx I, II, and III, all have now been shown to possess peroxidase activity and to rely on Trx as
a source of reducing equivalents for the reduction of H 2 O 2. Prx I and II are cytosolic
proteins, whereas Prx III is localized in mitochondria. Transient overexpression of Prx I or II
in cultured cells showed that they were able to eliminate the intracellular H 2 O 2 generated …
