Effects of magnesium on the production of extracellular matrix metalloproteinases in cultured rat vascular smooth muscle cells

H Yue, JD Lee, H Shimizu, H Uzui, Y Mitsuke, T Ueda - Atherosclerosis, 2003 - Elsevier
The precise correlation between magnesium and cardiovascular disease remains to be
established. Matrix metalloproteinases (MMPs) are expressed in coronary arterial
atherosclerotic lesions. MMP production in vascular smooth muscle cells (VSMCs) is
stimulated by growth factors such as platelet-derived growth factor (PDGF). To assess the
association between magnesium and MMPs, we examined the effects of different
extracellular magnesium concentrations (0–3.0 mmol/l) on MMPs production in cultured rat …