[HTML][HTML] Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysis
Y Zhang, R Guan, J Jiang, JJ Kopchick… - Journal of Biological …, 2001 - ASBMB
Growth hormone (GH) initiates its cellular action by properly dimerizing GH receptor (GHR).
A substantial fraction of circulating GH is complexed with a high-affinity GH-binding protein
(GHBP) that in many species can be generated by GHR proteolysis and shedding of the
receptor's ligand-binding extracellular domain. We previously showed that this proteolysis 1)
can be acutely promoted by the phorbol ester phorbol 12-myristate 13-acetate (PMA), 2)
requires a metalloprotease activity, 3) generates both shed GHBP and a membrane …
A substantial fraction of circulating GH is complexed with a high-affinity GH-binding protein
(GHBP) that in many species can be generated by GHR proteolysis and shedding of the
receptor's ligand-binding extracellular domain. We previously showed that this proteolysis 1)
can be acutely promoted by the phorbol ester phorbol 12-myristate 13-acetate (PMA), 2)
requires a metalloprotease activity, 3) generates both shed GHBP and a membrane …
