Regulation of the human Na/K-ATPase β1 gene promoter by mineralocorticoid and glucocorticoid receptors
A Derfoul, NM Robertson, JB Lingrel, DJ Hall… - Journal of Biological …, 1998 - ASBMB
Expression of the human Na/K-ATPase β1 subunit is regulated by a mineralocorticoid-and
glucocorticoid-responsive elements. Here we identified an MR and GR responsive element,
at positions− 650 to− 630, within the β1 gene promoter that is required for both MR and GR
activation. Independent expression of MR and GR activated by aldosterone or triamcinolone
acetonide (TA) leads to significant transactivation of the β1 promoter. Yet coexpression of
both receptors activated by aldosterone plus TA or cortisol results in a much lower induction …
glucocorticoid-responsive elements. Here we identified an MR and GR responsive element,
at positions− 650 to− 630, within the β1 gene promoter that is required for both MR and GR
activation. Independent expression of MR and GR activated by aldosterone or triamcinolone
acetonide (TA) leads to significant transactivation of the β1 promoter. Yet coexpression of
both receptors activated by aldosterone plus TA or cortisol results in a much lower induction …
