Clonidine and dexmedetomidine produce antinociceptive synergy in mouse spinal cord
CA Fairbanks, KF Kitto, HO Nguyen… - The Journal of the …, 2009 - pubs.asahq.org
Background Synergy between drugs manifests with increased potency and/or efficacy of the
combination relative to either agonist given alone. Synergy is typically observed between
drugs of different classes, as is the case with the alpha-adrenergic-opioid receptor synergy
often observed in preclinical studies. However, rare studies report synergy between agonists
of the same class. The current study examined the analgesic interaction between two
intrathecally injected alpha2-adrenergic receptor (AR) agonists previously thought to act at …
combination relative to either agonist given alone. Synergy is typically observed between
drugs of different classes, as is the case with the alpha-adrenergic-opioid receptor synergy
often observed in preclinical studies. However, rare studies report synergy between agonists
of the same class. The current study examined the analgesic interaction between two
intrathecally injected alpha2-adrenergic receptor (AR) agonists previously thought to act at …
