Immune responses in interleukin-2-deficient mice
TM Kündig, H Schorle, MF Bachmann, H Hengartner… - Science, 1993 - science.org
TM Kündig, H Schorle, MF Bachmann, H Hengartner, RM Zinkernagel, I Horak
Science, 1993•science.orgThe role of costimulatory signals in T cell induction was evaluated in mice lacking the
interleukin-2 (IL-2) gene. In vitro secondary antiviral T cell responses were absent unless IL-
2 was added, confirming the crucial role of IL-2 in vitro. In vivo, primary and secondary
cytotoxic T cell responses against vaccinia and lymphocytic choriomeningitis virus were
within normal ranges. B cell reactivity to vesicular stomatitis virus was not impaired. T helper
cell responses were delayed but biologically functional. Natural killer cell activity was …
interleukin-2 (IL-2) gene. In vitro secondary antiviral T cell responses were absent unless IL-
2 was added, confirming the crucial role of IL-2 in vitro. In vivo, primary and secondary
cytotoxic T cell responses against vaccinia and lymphocytic choriomeningitis virus were
within normal ranges. B cell reactivity to vesicular stomatitis virus was not impaired. T helper
cell responses were delayed but biologically functional. Natural killer cell activity was …
The role of costimulatory signals in T cell induction was evaluated in mice lacking the interleukin-2 (IL-2) gene. In vitro secondary antiviral T cell responses were absent unless IL-2 was added, confirming the crucial role of IL-2 in vitro. In vivo, primary and secondary cytotoxic T cell responses against vaccinia and lymphocytic choriomeningitis virus were within normal ranges. B cell reactivity to vesicular stomatitis virus was not impaired. T helper cell responses were delayed but biologically functional. Natural killer cell activity was markedly reduced but inducible. These normal in vivo immune responses in IL-2-deficient mice question the importance of IL-2 as defined by in vitro studies.
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