Acidic FGF regulation of hyperproliferation of fibroblasts in human autosomal dominant polycystic kidney disease
NT Kuo, JT Norman, PD Wilson - Biochemical and molecular medicine, 1997 - Elsevier
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by cystic tubule
enlargement and expansion of the interstitium associated with fibrosis. Our previous studies
have analyzed the increased proliferation of cystic epithelial cells and this study examines
the basis of increased proliferation of interstitial fibroblasts associated with ADPKD disease
progression. ADPKD fibroblasts show phenotypic alterationsin vitro, have acquired the
capacity to grow in soft agar, and show an increased mitogenic response to a variety of …
enlargement and expansion of the interstitium associated with fibrosis. Our previous studies
have analyzed the increased proliferation of cystic epithelial cells and this study examines
the basis of increased proliferation of interstitial fibroblasts associated with ADPKD disease
progression. ADPKD fibroblasts show phenotypic alterationsin vitro, have acquired the
capacity to grow in soft agar, and show an increased mitogenic response to a variety of …
