Alternate signalling pathways from the interleukin-2 receptor
JM Ellery, PJ Nicholls - Cytokine & growth factor reviews, 2002 - Elsevier
Interleukin-2 (IL-2) plays a major role in the proliferation of cell populations during an
immune reaction. The βc and γc subunits of the IL-2 receptor (IL-2R) are sufficient and
necessary for signal transduction. Despite lacking known catalytic domains, receptor
engagement leads to the activation of a diverse array protein tyrosine kinases (PTKs). In
resting or anergised T cells, Jak3 is not activated. Signals arising from the PROX domain of
the γc subunit activate p56lck (lck) leading to the induction of anti-apoptotic mechanisms …
immune reaction. The βc and γc subunits of the IL-2 receptor (IL-2R) are sufficient and
necessary for signal transduction. Despite lacking known catalytic domains, receptor
engagement leads to the activation of a diverse array protein tyrosine kinases (PTKs). In
resting or anergised T cells, Jak3 is not activated. Signals arising from the PROX domain of
the γc subunit activate p56lck (lck) leading to the induction of anti-apoptotic mechanisms …
