Endogenous mutagens and the causes of aging and cancer
BN Ames, LS Gold - … Research/Fundamental and Molecular Mechanisms of …, 1991 - Elsevier
A very large oxidative damage rate to DNA occurs as part of normal metabolism. In each rat
cell the steady-state level is estimated to be about 10 6 oxidative adducts and about 10 5
new adducts are formed daily. It is argued that this endogenous DNA damage is a major
contributor to aging and the degenerative diseases of aging, such as cancer. The oxidative
damage rate in mammalian species with a high metabolic rate, short life span, and high age-
specific cancer rate is much higher than the rate in humans, a long-lived creature with a …
cell the steady-state level is estimated to be about 10 6 oxidative adducts and about 10 5
new adducts are formed daily. It is argued that this endogenous DNA damage is a major
contributor to aging and the degenerative diseases of aging, such as cancer. The oxidative
damage rate in mammalian species with a high metabolic rate, short life span, and high age-
specific cancer rate is much higher than the rate in humans, a long-lived creature with a …