[HTML][HTML] The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter
TB Deramaudt, MM Sachdeva, MP Wescott… - Journal of biological …, 2006 - ASBMB
Keratin 19 is a member of the cytokeratin family that is critical for maintenance of cellular
architecture and organization, especially of epithelia. The pancreas has three distinct cell
types, ductal, acinar, and islet, each with different functions. Embryologically, the pancreatic
and duodenal homeobox 1 (PDX1) homeodomain protein is critical for the initiation of all
pancreatic lineages; however, the later differentiation of the endocrine pancreas is uniquely
dependent upon high PDX1 expression, whereas PDX1 is down-regulated in the ductal and …
architecture and organization, especially of epithelia. The pancreas has three distinct cell
types, ductal, acinar, and islet, each with different functions. Embryologically, the pancreatic
and duodenal homeobox 1 (PDX1) homeodomain protein is critical for the initiation of all
pancreatic lineages; however, the later differentiation of the endocrine pancreas is uniquely
dependent upon high PDX1 expression, whereas PDX1 is down-regulated in the ductal and …