[HTML][HTML] Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker
Q Zhou, M Cadrin, H Herrmann, CH Chen… - Journal of Biological …, 2006 - ASBMB
Keratin polypeptide 20 (K20) is an intermediate filament protein with preferential expression
in epithelia of the stomach, intestine, uterus, and bladder and in Merkel cells of the skin. K20
expression is used as a marker to distinguish metastatic tumor origin, but nothing is known
regarding its regulation and function. We studied K20 phosphorylation as a first step toward
understanding its physiologic role. K20 phosphorylation occurs preferentially on serine, with
a high stoichiometry as compared with keratin polypeptides 18 and 19. Mass spectrometry …
in epithelia of the stomach, intestine, uterus, and bladder and in Merkel cells of the skin. K20
expression is used as a marker to distinguish metastatic tumor origin, but nothing is known
regarding its regulation and function. We studied K20 phosphorylation as a first step toward
understanding its physiologic role. K20 phosphorylation occurs preferentially on serine, with
a high stoichiometry as compared with keratin polypeptides 18 and 19. Mass spectrometry …