Expression of peripherin in ubiquinated inclusions of amyotrophic lateral sclerosis
CZ He, AP Hays - Journal of the neurological sciences, 2004 - Elsevier
We evaluated the expression of the type III intermediate filament (IF) protein, peripherin
(PRP), in ubiquinated inclusions of motor neurons in amyotrophic lateral sclerosis (ALS). A
previous study showed that overexpression of PRP in transgenic mice induces motor neuron
disease with formation of PRP-containing inclusions before onset of symptoms [J. Cell Biol.
147 (3)(1999) 531]. To determine whether PRP inclusions occur in the human disease, we
applied doublelabeling immunofluorescence to paraffin sections of the spinal cord obtained …
(PRP), in ubiquinated inclusions of motor neurons in amyotrophic lateral sclerosis (ALS). A
previous study showed that overexpression of PRP in transgenic mice induces motor neuron
disease with formation of PRP-containing inclusions before onset of symptoms [J. Cell Biol.
147 (3)(1999) 531]. To determine whether PRP inclusions occur in the human disease, we
applied doublelabeling immunofluorescence to paraffin sections of the spinal cord obtained …
