Species differences in the effects of substance P on inositol trisphosphate accumulation and cyclic AMP formation, and on contraction in isolated iris sphincter of the …
SD Tachado, RA Akhtar, SYK Yousufzai… - Experimental eye …, 1991 - Elsevier
The effects of substance P (SP) on inositol trisphosphate (IP 3) accumulation, myosin light
chain (MLC) phosphorylation, cAMP formation and contraction were studied in iris sphincter
smooth muscle of different mammalian species. SP receptor density was also examined in
membrane fractions from this tissue. The data obtained can be summarized as follows.(1) In
the iris sphincters of rabbit, bovine and pig, SP receptors are coupled to the phospholipase
C system, whereas in dog, cat and human these receptors are coupled to the adenylate …
chain (MLC) phosphorylation, cAMP formation and contraction were studied in iris sphincter
smooth muscle of different mammalian species. SP receptor density was also examined in
membrane fractions from this tissue. The data obtained can be summarized as follows.(1) In
the iris sphincters of rabbit, bovine and pig, SP receptors are coupled to the phospholipase
C system, whereas in dog, cat and human these receptors are coupled to the adenylate …
