The balance between IL-1 and IL-1Ra in disease
WP Arend - Cytokine & growth factor reviews, 2002 - Elsevier
IL-1 is an important mediator of inflammation and tissue damage in multiple organs, both in
experimental animal models of disease and in human diseases. The IL-1 family consists of
two agonists, IL-1α and IL-1β, two receptors, biologically active IL-1RI and inert IL-1RII, and
a specific receptor antagonist, IL-1Ra. The balance between IL-1 and IL-1Ra in local tissues
plays an important role in the susceptibility to and severity of many diseases. An allelic
polymorphism in the IL-1Ra gene has been associated with a variety of human diseases …
experimental animal models of disease and in human diseases. The IL-1 family consists of
two agonists, IL-1α and IL-1β, two receptors, biologically active IL-1RI and inert IL-1RII, and
a specific receptor antagonist, IL-1Ra. The balance between IL-1 and IL-1Ra in local tissues
plays an important role in the susceptibility to and severity of many diseases. An allelic
polymorphism in the IL-1Ra gene has been associated with a variety of human diseases …
