The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction
ML Lupher, N Rao, MJ Eck, H Band - Immunology today, 1999 - cell.com
ML Lupher, N Rao, MJ Eck, H Band
Immunology today, 1999•cell.comThe Cbl protooncoprotein has recently emerged as a component of tyrosine kinase-
mediated signal transduction in a variety of cell types. Here, we discuss evidence that
supports a role for Cbl as a novel negative regulator of immune receptor signaling, and
present models for its mode of function.
mediated signal transduction in a variety of cell types. Here, we discuss evidence that
supports a role for Cbl as a novel negative regulator of immune receptor signaling, and
present models for its mode of function.
Abstract
The Cbl protooncoprotein has recently emerged as a component of tyrosine kinase-mediated signal transduction in a variety of cell types. Here, we discuss evidence that supports a role for Cbl as a novel negative regulator of immune receptor signaling, and present models for its mode of function.
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