Function of prostanoid receptors: studies on knockout mice
T Kobayashi, S Narumiya - Prostaglandins & other lipid mediators, 2002 - Elsevier
Prostanoids consisting of the prostaglandins (PGs) and the thromboxanes (TXs) are the
cyclooxygenase metabolites of arachidonic acid. They exert a range of actions mediated by
their respective receptors expressed in the target cells. The receptors include the DP, EP,
FP, IP and TP receptors for PGD, PGE, PGF, PGI and TXA, respectively. Furthermore, EP is
subdivided into four subtypes, EP1, EP2, EP3 and EP4, which are encoded by different
genes and differ in their responses to various agonists and antagonists. Recent …
cyclooxygenase metabolites of arachidonic acid. They exert a range of actions mediated by
their respective receptors expressed in the target cells. The receptors include the DP, EP,
FP, IP and TP receptors for PGD, PGE, PGF, PGI and TXA, respectively. Furthermore, EP is
subdivided into four subtypes, EP1, EP2, EP3 and EP4, which are encoded by different
genes and differ in their responses to various agonists and antagonists. Recent …
Distribution and function of prostanoid receptors: studies from knockout mice
Y Sugimoto, S Narumiya, A Ichikawa - Progress in lipid research, 2000 - Elsevier
Recent developments in the molecular biology of the prostanoid receptors has allowed the
investigation of the physiological roles of each individual receptor type and subtype. The
following article reports the prostanoid receptor distributions deduced from Northern blot and
in situ hybridization analyses, summarizes the phenotypes of each receptor knockout mice,
and discusses recent studies investigating the effects of each receptor deficiency on the
inflammatory response and female reproductive processes. The combination of expression …
investigation of the physiological roles of each individual receptor type and subtype. The
following article reports the prostanoid receptor distributions deduced from Northern blot and
in situ hybridization analyses, summarizes the phenotypes of each receptor knockout mice,
and discusses recent studies investigating the effects of each receptor deficiency on the
inflammatory response and female reproductive processes. The combination of expression …