Transcriptional control of epidermal specification and differentiation
X Dai, JA Segre - Current opinion in genetics & development, 2004 - Elsevier
X Dai, JA Segre
Current opinion in genetics & development, 2004•ElsevierRecent experiments reveal the role of transcription factors in integrating upstream signals to
execute specification and differentiation of epidermal cells. Based on the skin phenotype
observed with misregulation of transcription factors such as p63, c-Myc, RelA, pRb, Klf4 and
others, their function in controlling proliferation and differentiation is dissected.
Understanding the pathways regulated by these factors and their coordinate interactions
remains a challenge for the future.
execute specification and differentiation of epidermal cells. Based on the skin phenotype
observed with misregulation of transcription factors such as p63, c-Myc, RelA, pRb, Klf4 and
others, their function in controlling proliferation and differentiation is dissected.
Understanding the pathways regulated by these factors and their coordinate interactions
remains a challenge for the future.
Recent experiments reveal the role of transcription factors in integrating upstream signals to execute specification and differentiation of epidermal cells. Based on the skin phenotype observed with misregulation of transcription factors such as p63, c-Myc, RelA, pRb, Klf4 and others, their function in controlling proliferation and differentiation is dissected. Understanding the pathways regulated by these factors and their coordinate interactions remains a challenge for the future.
Elsevier
