Lipopenia and skin barrier abnormalities in DGAT2-deficient mice
SJ Stone, HM Myers, SM Watkins, BE Brown… - Journal of Biological …, 2004 - ASBMB
The synthesis of triglycerides is catalyzed by two known acyl-CoA: diacylglycerol
acyltransferase (DGAT) enzymes. Although they catalyze the same biochemical reaction,
these enzymes share no sequence homology, and their relative functions are poorly
understood. Gene knockout studies in mice have revealed that DGAT1 contributes to
triglyceride synthesis in tissues and plays an important role in regulating energy metabolism
but is not essential for life. Here we show that DGAT2 plays a fundamental role in …
acyltransferase (DGAT) enzymes. Although they catalyze the same biochemical reaction,
these enzymes share no sequence homology, and their relative functions are poorly
understood. Gene knockout studies in mice have revealed that DGAT1 contributes to
triglyceride synthesis in tissues and plays an important role in regulating energy metabolism
but is not essential for life. Here we show that DGAT2 plays a fundamental role in …
