Interleukin-15: a new cytokine target for the treatment of inflammatory diseases
IB McInnes, JA Gracie - Current opinion in pharmacology, 2004 - Elsevier
Interleukin (IL)-15 is a pleiotropic pro-inflammatory cytokine that is expressed in several
inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary
inflammatory diseases. IL-15 promotes activation of T cells, neutrophils and macrophages,
and is critical to dendritic cell function in several model systems. Recent emerging data
suggest that IL-15 may serve as a useful therapeutic target across a range of disease states.
Advances in the past year highlight the beneficial effect of IL-15 neutralisation in models of …
inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary
inflammatory diseases. IL-15 promotes activation of T cells, neutrophils and macrophages,
and is critical to dendritic cell function in several model systems. Recent emerging data
suggest that IL-15 may serve as a useful therapeutic target across a range of disease states.
Advances in the past year highlight the beneficial effect of IL-15 neutralisation in models of …
