Fatty acid metabolism and vascular disease
CF Semenkovich - Trends in cardiovascular medicine, 2004 - Elsevier
Fatty acid metabolism is abnormal in insulin-resistant states that increase the risk of
atherosclerosis such as type 2 diabetes and the metabolic syndrome. How fatty acids
promote vascular disease is poorly understood, but lipoprotein lipase and peroxisome
proliferator-activated receptor α (PPARα)—physiologically related proteins involved in fatty
acid metabolism—may be involved. Glucocorticoid metabolism is also abnormal in insulin-
resistant states and may promote several components of the metabolic syndrome. Recent …
atherosclerosis such as type 2 diabetes and the metabolic syndrome. How fatty acids
promote vascular disease is poorly understood, but lipoprotein lipase and peroxisome
proliferator-activated receptor α (PPARα)—physiologically related proteins involved in fatty
acid metabolism—may be involved. Glucocorticoid metabolism is also abnormal in insulin-
resistant states and may promote several components of the metabolic syndrome. Recent …
