[HTML][HTML] Monocyte Chemoattractant Protein-3 Is a Functional Ligand for CC Chemokine Receptors 1 and 2B (∗)
C Combadiere, SK Ahuja, J Van Damme… - Journal of Biological …, 1995 - ASBMB
The CC chemokine monocyte chemoattractant protein-3 (MCP-3) activates human
monocytes, lymphocytes, basophils, and eosinophils. MCP-3 has been reported to induce
[Ca 2+] i changes in cells transfected with the monocyte-selective MCP-1 receptor 2B (CC
CKR2B) and competes for 125 I-MCP-1 binding on CC CKR2B, suggesting that it may
mediate monocyte responses to MCP-3. However, we now show that MCP-3 is a ligand and
potent agonist for the macrophage inflammatory protein-1α (MIP-1α)/regulated on activation …
monocytes, lymphocytes, basophils, and eosinophils. MCP-3 has been reported to induce
[Ca 2+] i changes in cells transfected with the monocyte-selective MCP-1 receptor 2B (CC
CKR2B) and competes for 125 I-MCP-1 binding on CC CKR2B, suggesting that it may
mediate monocyte responses to MCP-3. However, we now show that MCP-3 is a ligand and
potent agonist for the macrophage inflammatory protein-1α (MIP-1α)/regulated on activation …