Human breast carcinoma cells synthesize a protein immunorelated to platelet glycoprotein-lbα with different functional properties
L Oleksowicz, JP Dutcher, M DeLeon-Fernandez… - Journal of Laboratory …, 1997 - Elsevier
Although tumor cell-induced platelet aggregation is thought to mediate an early step in the
metastatic process, little is known about tumor adhesive receptors responsible for the initial
platelet-tumor attachments. Because our preliminary work demonstrated that a platelet-
immunorelated glycoprotein Ibα (GPIbα) receptor expressed by the human breast carcinoma
cell line MCF-7 participates in tumorinduced platelet aggregation, we examined the
synthesis and functional characteristics of this MCF-7-immunorelated GPlbα. When 35S …
metastatic process, little is known about tumor adhesive receptors responsible for the initial
platelet-tumor attachments. Because our preliminary work demonstrated that a platelet-
immunorelated glycoprotein Ibα (GPIbα) receptor expressed by the human breast carcinoma
cell line MCF-7 participates in tumorinduced platelet aggregation, we examined the
synthesis and functional characteristics of this MCF-7-immunorelated GPlbα. When 35S …
