[HTML][HTML] Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells
R Bagheri-Yarmand, M Mandal, AH Taludker… - Journal of Biological …, 2001 - ASBMB
Etk/Bmx, a member of the Tec family of nonreceptor protein-tyrosine kinases, is
characterized by an N-terminal pleckstrin homology domain and has been shown to be a
downstream effector of phosphatidylinositol 3-kinase. P21-activated kinase 1 (Pak1),
another well characterized effector of phosphatidylinositol 3-kinase, has been implicated in
the progression of breast cancer cells. In this study, we characterized the role of Etk in
mammary development and tumorigenesis and explored the functional interactions between …
characterized by an N-terminal pleckstrin homology domain and has been shown to be a
downstream effector of phosphatidylinositol 3-kinase. P21-activated kinase 1 (Pak1),
another well characterized effector of phosphatidylinositol 3-kinase, has been implicated in
the progression of breast cancer cells. In this study, we characterized the role of Etk in
mammary development and tumorigenesis and explored the functional interactions between …