Cytotoxic T cells against a peptide of Yo protein in patients with paraneoplastic cerebellar degeneration and anti-Yo antibody
M Tanaka, K Tanaka, S Tokiguchi, K Shinozawa… - Journal of the …, 1999 - Elsevier
Anti-Yo antibodies are present in the sera and cerebrospinal fluid of some patients with
paraneoplastic cerebellar degeneration (PCD), but there is no evidence that the presence of
anti-Yo antibodies causes the Purkinje cell loss seen in PCD patients. We examined the
level of cytotoxic T lymphocyte (CTL) activity against a nine-amino acid peptide of the Yo
protein using the Human Leukocyte Antigen-(HLA-) based approach called reverse
immunogenetics. Mononuclear cells (MNCs) were isolated from the peripheral venous blood …
paraneoplastic cerebellar degeneration (PCD), but there is no evidence that the presence of
anti-Yo antibodies causes the Purkinje cell loss seen in PCD patients. We examined the
level of cytotoxic T lymphocyte (CTL) activity against a nine-amino acid peptide of the Yo
protein using the Human Leukocyte Antigen-(HLA-) based approach called reverse
immunogenetics. Mononuclear cells (MNCs) were isolated from the peripheral venous blood …