The history and theory of the doubly labeled water technique

RS John - The American journal of clinical nutrition, 1998 - Elsevier
Scientists have been measuring energy expenditure by using gas exchange for the past 200
y. This technique is based on earlier work in the 1660s. Gas exchange in respirometers
provides accurate and repeatable measures of resting metabolic rate. However, it is
impossible to duplicate in a respirometry chamber the diversity of human behaviors that
influence energy expenditure. The doubly labeled water technique is an isotope-based
method that measures the energy expenditure of unencumbered subjects from the …