Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow.
G Ambrosio, JL Zweier, C Duilio, P Kuppusamy… - Journal of Biological …, 1993 - ASBMB
Previous in vitro studies have shown that isolated mitochondria can generate oxygen
radicals. However, whether a similar phenomenon can also occur in intact organs is
unknown. In the present study, we tested the hypothesis that resumption of mitochondrial
respiration upon reperfusion might be a mechanism of oxygen radical formation in
postischemic hearts, and that treatment with inhibitors of mitochondrial respiration might
prevent this phenomenon. Three groups of Langendorff-perfused rabbit hearts were …
radicals. However, whether a similar phenomenon can also occur in intact organs is
unknown. In the present study, we tested the hypothesis that resumption of mitochondrial
respiration upon reperfusion might be a mechanism of oxygen radical formation in
postischemic hearts, and that treatment with inhibitors of mitochondrial respiration might
prevent this phenomenon. Three groups of Langendorff-perfused rabbit hearts were …
