Platelet genomics and proteomics in human health and disease
IC Macaulay, P Carr, A Gusnanto… - The Journal of …, 2005 - Am Soc Clin Investig
The Journal of clinical investigation, 2005•Am Soc Clin Investig
Proteomic and genomic technologies provide powerful tools for characterizing the multitude
of events that occur in the anucleate platelet. These technologies are beginning to define the
complete platelet transcriptome and proteome as well as the protein-protein interactions
critical for platelet function. The integration of these results provides the opportunity to
identify those proteins involved in discrete facets of platelet function. Here we summarize the
findings of platelet proteome and transcriptome studies and their application to diseases of …
of events that occur in the anucleate platelet. These technologies are beginning to define the
complete platelet transcriptome and proteome as well as the protein-protein interactions
critical for platelet function. The integration of these results provides the opportunity to
identify those proteins involved in discrete facets of platelet function. Here we summarize the
findings of platelet proteome and transcriptome studies and their application to diseases of …
Proteomic and genomic technologies provide powerful tools for characterizing the multitude of events that occur in the anucleate platelet. These technologies are beginning to define the complete platelet transcriptome and proteome as well as the protein-protein interactions critical for platelet function. The integration of these results provides the opportunity to identify those proteins involved in discrete facets of platelet function. Here we summarize the findings of platelet proteome and transcriptome studies and their application to diseases of platelet function.
The Journal of Clinical Investigation