[HTML][HTML] Differential role of the α1C subunit tails in regulation of the Cav1. 2 channel by membrane potential, β subunits, and Ca2+ ions
E Kobrinsky, S Tiwari, VA Maltsev, JB Harry… - Journal of Biological …, 2005 - ASBMB
Voltage-gated Ca v 1.2 channels are composed of the pore-forming α 1C and auxiliary β
and α 2 δ subunits. Voltage-dependent conformational rearrangements of the α 1C subunit
C-tail have been implicated in Ca 2+ signal transduction. In contrast, the α 1C N-tail
demonstrates limited voltage-gated mobility. We have asked whether these properties are
critical for the channel function. Here we report that transient anchoring of the α 1C subunit C-
tail in the plasma membrane inhibits Ca 2+-dependent and slow voltage-dependent …
and α 2 δ subunits. Voltage-dependent conformational rearrangements of the α 1C subunit
C-tail have been implicated in Ca 2+ signal transduction. In contrast, the α 1C N-tail
demonstrates limited voltage-gated mobility. We have asked whether these properties are
critical for the channel function. Here we report that transient anchoring of the α 1C subunit C-
tail in the plasma membrane inhibits Ca 2+-dependent and slow voltage-dependent …
