Downregulation of Ca2+ and Mg2+ transport proteins in the kidney explains tacrolimus (FK506)-induced hypercalciuria and hypomagnesemia
T Nijenhuis, JGJ Hoenderop… - Journal of the American …, 2004 - journals.lww.com
FK506 (tacrolimus) and dexamethasone are potent immunosuppressants known to induce
significant side effects on mineral homeostasis, including hypercalciuria and
hypomagnesemia. However, the underlying molecular mechanisms remain unknown. The
present study investigated the effects of FK506 and dexamethasone on the expression of
proteins involved in active Ca 2+ reabsorption: the epithelial Ca 2+ channel TRPV5 and the
cytosolic Ca 2+-binding protein calbindin-D 28K. In addition, the renal expression of the …
significant side effects on mineral homeostasis, including hypercalciuria and
hypomagnesemia. However, the underlying molecular mechanisms remain unknown. The
present study investigated the effects of FK506 and dexamethasone on the expression of
proteins involved in active Ca 2+ reabsorption: the epithelial Ca 2+ channel TRPV5 and the
cytosolic Ca 2+-binding protein calbindin-D 28K. In addition, the renal expression of the …
