Setting: TGF-β1 has been implicated as an important mediator of immuno-suppression in
clinical tuberculosis. Objective: The objective was to determine the role of TGF-β1 in
experimental pulmonary tuberculosis in the guinea pig. Design: Groups of guinea pigs,
maintained on either a low protein (LP) diet or an isocaloric high protein (HP) diet. were
challenged via the respiratory route with virulent Mycobacterium tuberculosis H37Rv. Ten
days post-infection, guinea pigs were given daily intraperitoneal injections of recombinant …