Gonadal and adrenal sex steroids in ankylosing spondylitis
LJG Gooren, EJ Giltay, D Van Schaardenburg… - … Disease Clinics of North …, 2000 - Elsevier
Several reports indicate that gonadal hormones may be relevant in the etiology of
ankylosing spondylitis (AS), but the evidence for genetic and immunologic factors in the
etiology of AS is presently more robust. There remains, however, a possibility that endocrine
factors interact with genetic and immune mechanisms of the disease. The increased
susceptibility for AS and other forms of spondyloarthropathy in individuals positive for the
genetic marker human leukocyte antigen (HLA)-B27 is well documented. 24, 63, 86 It is …
ankylosing spondylitis (AS), but the evidence for genetic and immunologic factors in the
etiology of AS is presently more robust. There remains, however, a possibility that endocrine
factors interact with genetic and immune mechanisms of the disease. The increased
susceptibility for AS and other forms of spondyloarthropathy in individuals positive for the
genetic marker human leukocyte antigen (HLA)-B27 is well documented. 24, 63, 86 It is …
