Characterization of a spontaneously occurring arthritis in male DBA/1 mice
C Nordling, A Karlsson‐Parra… - … : Official Journal of …, 1992 - Wiley Online Library
C Nordling, A Karlsson‐Parra, L Jansson, R Holmdahl, L Klareskog
Arthritis & Rheumatism: Official Journal of the American College …, 1992•Wiley Online LibraryObjective. We studied the incidence, severity, histopathologic features, and status of
infection in a spontaneous polyarthritis which occurs in male DBA/1 mice. Methods. Over a
25‐week period, the arthritis was evaluated macroscopically in naive mice of different
strains. The histopathology was evaluated at different phases of the disease. Virologic and
bacteriologic investigations were performed. Results. The arthritis occurs in∼ 80% of aging
male DBA/1 mice. The disease is chronic and destructive, and the affected joints are …
infection in a spontaneous polyarthritis which occurs in male DBA/1 mice. Methods. Over a
25‐week period, the arthritis was evaluated macroscopically in naive mice of different
strains. The histopathology was evaluated at different phases of the disease. Virologic and
bacteriologic investigations were performed. Results. The arthritis occurs in∼ 80% of aging
male DBA/1 mice. The disease is chronic and destructive, and the affected joints are …
Abstract
Objective. We studied the incidence, severity, histopathologic features, and status of infection in a spontaneous polyarthritis which occurs in male DBA/1 mice.
Methods. Over a 25‐week period, the arthritis was evaluated macroscopically in naive mice of different strains. The histopathology was evaluated at different phases of the disease. Virologic and bacteriologic investigations were performed.
Results. The arthritis occurs in ∼80% of aging male DBA/1 mice. The disease is chronic and destructive, and the affected joints are characterized by synovial lining proliferation and infiltration of inflammatory cells, mainly mononuclear. The susceptibility appears to be dependent on both sex‐linked and non‐sex‐linked genes, since female DBA/1 mice are not affected and since male BALB/c housed in the same colony are only marginally affected.
Conclusion. This first description of a spontaneous arthritis in aging male DBA/1 mice should provide new opportunities to study general features of a chronic and intermittent arthritis in a well‐characterized strain, in which no generalized aberrations of the immune system have been described.
Wiley Online Library