A new animal model for human preeclampsia: ultra-lowdose endotoxin infusion in pregnant rats
MM Faas, GA Schuiling, JFW Baller… - American journal of …, 1994 - Elsevier
Objective: An animal model for preeclampsia was developed by means of an ultra-low-dose
endotoxin infusion protocol in conscious pregnant rats. Study Design: Rats received a
permanent jugular vein cannula on day aof pregnancy, through which endotoxin (1.0 μg/kg
body weight)(n= 10) or saline solution (n= 6) was infused during 1 hour on day 14 of
pregnancy. Blood pressure, albuminuria, and platelet counts were measured, and
histopathologic studies was performed in these rats. Results: A significant increase of blood …
endotoxin infusion protocol in conscious pregnant rats. Study Design: Rats received a
permanent jugular vein cannula on day aof pregnancy, through which endotoxin (1.0 μg/kg
body weight)(n= 10) or saline solution (n= 6) was infused during 1 hour on day 14 of
pregnancy. Blood pressure, albuminuria, and platelet counts were measured, and
histopathologic studies was performed in these rats. Results: A significant increase of blood …
