Evidence of splanchnic-brain signaling in inhibition of ingestive behavior by middle molecules
AH MAMOUN, PER SÖDERSTEN… - Journal of the …, 1999 - journals.lww.com
Anorexia, nausea, and vomiting are common symptoms of uremic intoxication. Fractions in
the middle molecule weight range, isolated from normal urine and uremic plasma
ultrafiltrate, inhibit ingestive behavior in the rat. To investigate their site of action and
specificity, male rats were injected intraperitoneally, intravenously, or
intracerebroventricularly with concentrated fractions of uremic plasma ultrafiltrate or normal
urine (molecular weight range: 1.0 to 5.0 kD) and tested for ingestive and sexual behavior …
the middle molecule weight range, isolated from normal urine and uremic plasma
ultrafiltrate, inhibit ingestive behavior in the rat. To investigate their site of action and
specificity, male rats were injected intraperitoneally, intravenously, or
intracerebroventricularly with concentrated fractions of uremic plasma ultrafiltrate or normal
urine (molecular weight range: 1.0 to 5.0 kD) and tested for ingestive and sexual behavior …
