Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective …
The molecular basis for the beneficial impact of essential omega-3 fatty acids is of
considerable interest. Recently, novel mediators generated from eicosapentaenoic acid
(EPA) and docosahexaenoic acid (DHA) that displayed potent bioactions were first identified
in resolving inflammatory exudates [J. Exp. Med. 192 (2000) 1197; J. Exp. Med. 196 (2002)
1025] and in tissues enriched with DHA [J. Exp. Med. 196 (2002) 1025; J. Biol. Chem. 278
(2003) 14677]. The trivial names Resolvin (resolution phase interaction products) and …
considerable interest. Recently, novel mediators generated from eicosapentaenoic acid
(EPA) and docosahexaenoic acid (DHA) that displayed potent bioactions were first identified
in resolving inflammatory exudates [J. Exp. Med. 192 (2000) 1197; J. Exp. Med. 196 (2002)
1025] and in tissues enriched with DHA [J. Exp. Med. 196 (2002) 1025; J. Biol. Chem. 278
(2003) 14677]. The trivial names Resolvin (resolution phase interaction products) and …
